Mightex OASIS Macro

Mesoscope for Optical Imaging and Targeted Optogenetics


The OASIS Macro is a mesoscope for all-optical targeted optogenetics, calcium imaging, and intrinsic imaging. The OASIS Macro enables researchers to simultaneously image the entire mouse cortex and perform targeted optogenetics (with Mightex’s market-leading Polygon DMD illuminator).

  • Large field of view for in vivo imaging and optogenetics
  • Targeted optogenetics
  • Reconfigurable mesoscope
  • Designed for in vivo experiments


Reconfigurable in vivo Mesoscope for Optical Imaging and Optogenetics

Mightex’s OASIS Macro is designed as a reconfigurable mesoscope for in vivo imaging and optogenetics. The final system can be tailored to performance requirements for unique applications. This can include major features such as adding a second and third illumination source, or a dual-camera imaging system, as well as fine details including compatibility features for certain cameras and objectives.





OASIS Macro Key Features


Large Field of View Calcium Imaging and Intrinsic Imaging

Field of View

The OASIS Macro is designed to image the activity of thousands of neuronal populations across the entire cortex of a head-fixed mouse or large cortical areas of an awake animal. The lenses compatible with the OASIS Macro provide a large field of view, compared to conventional microscopes.


Cortex-Wide Targeted Optogenetics

Perform region-specific targeted optogenetics or stimulate the entire cortical area with widefield optogenetics. The addition of Mightex’s Polygon DMD illuminator to the OASIS Macro enables targeted patterned illumination of regions or cells of interest.


Video: Mightex OASIS Macro Silasi

Synchronize with Behavioural or Electrophysiology Equipment

Easily synchronize imaging or optogenetics with other lab equipment. Synchronize with your stimulation patterns or imaging with electrophysiology or behavioural equipment.


Simplistic Mesoscope Design for in vivo Experiments

The OASIS Macro is designed for in vivo experiments with a minimalist design. A heavy-duty precision XYZ stage is mounted on the support structure and the OASIS optical assembly is in turn mounted on the XYZ stage. The XYZ stage controls the lateral motion as well as the focus of the system.


Compatible with Third-Party Scientific Cameras

When imaging indicators in vivo, scientists need ways to reliably and confidently collect and analyse the signals obtained. Our platform supports the use of scientific-grade cameras that maximize the quality and temporal resolution of the image acquisition. Compatible with any C-mount camera or multiple cameras.



Also See:


Publications and White Papers

on the Mightex OASIS Macro
(manufacturer's website)




Related Products:


Mightex OASIS Micro

In Vivo celluar resolution optogenetics
and imaging System

OASIS Implant

Mightex OASIS Implant

Platform for in vivo optogenetics
and Ca²⁺ imaging


Mightex OASIS Implant ROAM

Rotation adaptive mechanism
for OASIS Implant

Deep-Brain Headmount

Deep-Brain Headmount

for Mightex OASIS Implant

Large Field of View Headmount

Large Field of View Headmount

for Mightex OASIS Implant

Mightex High Power Fiber-Coupled LED Light Source

Fiber-Coupled LED Light Sources

i.e. from Mightex

Mightex GCS-series high-power LED source

Lightguide Coupled LED Sources

(Mightex GCS-series)


Mightex Polygon

Photostimulation and optogenetics