This system employs a stable isolation table on which the specimen and the micromanipulators can both be fixed independently to the microscope. With the microscope firmly fixed in position, the base can move in both X and Y planes. This allows the operator to change the observation position without moving either the specimen or the micromanipulators. The table is designed to accommodate any brand of microscope, so no adjustment mechanism is necessary. Vertical adjustment is easily performed by using spacers. The stage is supported by four large pillars whose outstanding rigidity and anti-vibration characteristics are further reinforced by added crossbeams. Holes provided in the wide, thick stainless steel stage allow the operator to set up several micromanipulators in any position required, by means of magnets or screws. The X, Y stage incorporates several large bearings to ensure smooth, stable movement of even a heavy microscope. Even the heaviest microscopes can be moved smoothly and easily with the large handles, which are comfortable to operate using just one hand.