The XenoWorks Micromanipulator has been designed around our hugely-successful MP-285 electrophysiology micromanipulator, with the addition of a smooth-moving adjustable inverted joystick. Because the motor drive is based on an electrophysiology design, the XenoWorks Micromanipulator is extremely stable and resistant to ambient vibration. This stability also makes this manipulator an ideal platform for use in conjunction with the PrimeTech PMM-150FU piezo impact drive for applications such as mouse nuclear transfer and intracytoplasmic sperm injection.

FEATURES

   Height- and tension-adjustable inverted joystick for optimal ergonomics 
   Exceptionally smooth and responsive micropipette movement
   Variable movement range - 6 settings from coarse to ultra-fine   
   User definable memory positions, including “Work” and z-axis lower limit
   A wide 25mm of travel in all three axes

The joystick offers an unprecedented level of user comfort during operation. The use of an inverted joystick in conjunction with an almost zero-profile base allows the operator to rest their hands and forearms on the bench surface, reducing the risk of repetitive strain injuries. The function keys can be located and activated by touch, obviating the need to look away from the microscope, saving time. Another time saving feature is the "Setup" function. Activating the setup function places the micromanipulator in the optimum position prior to beginning work (halfway on the Y-axis, three-quarters down on the Z-axis and three-quarters inwards on the X-axis). Once the manipulator is in the default setup position, the micropipette tip will already be projecting into the microscope's optical path, reducing the time taken to find the pipette tip down the microscope. This also ensures that there is adequate travel range in all axes of motion prior to starting work. The micromanipulator uses a pre-programmed "Home" position for fast micropipette exchange, and the ability to determine a "Work" position which can be returned to with the press of a button. The micromanipulator requires no programming and next to no learning time once set up and configured for a particular microscope.

The configuration of any microinjection system will depend upon the application for which it is used. Some common applications and system configurations are:

   Zygote pronuclear DNA microinjection
   Embryonic stem cell transfer into blastocyst
   Intracytoplasmic Sperm Injection (ICSI)
   Piezo-assisted ICSI
   Microinjection of cultured, adherent cells
   Somatic cell nuclear transfer

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