XenoWorksTM 

Modular Microinjection System

SUTTER INSTRUMENT

                                               

XenoWorksTM is a modular microinjection system designed to meet a wide variety of application needs.  SUTTER´s experience with precision motor control has culminated in this state-of-the-art system. The XenoWorksTM Micromanipulator uses a classic inverted joystick design for excellent ergonomics, intuitively linking the user with the micropipette.  Combined with our smooth, responsive stepper-motor drives, the XenoWorksTM Manipulator provides exceptional mechanical stability, sensitivity, and range of movement.

The XenoWorksTM Digital Microinjector was designed for precision manipulation of cells via an easy-to-use interface. The Digital Microinjector employs a self-contained vacuum channel for gentle suspension-cell holding applications.  A second channel is available for both high-pressure injection and gentle positive/negative pressure for transfer of embryonic stem cells. Both injection duration and pressure are easily selectable using rotary knobs on the remote interface.  The internal low-speed compressor removes the need for an external pressure supply. The XenoWorksTM family also includes the Analog Microinjector for simple cell holding and transfer applications, which incorporates the same smooth response and ergonomic design of our other XenoWorksTM products.

TYPICAL APPLICATIONS

   Pronuclear microinjection of DNA into  mouse zygote
   Embryonic stem cell transfer into blastocysts
   Somatic cell nuclear transfer

   Intracytoplasmic sperm injection (ICSI)
   Piezo-assisted sperm-mediated transgenesis and nuclear ransfer
    
                                        Contact SPT for suitability of XenoWorks for applications  not listed here       
    
    

SYSTEM FEATURES


XENOWORKS MICROMANIPULATOR

   Height- and tension-adjustable inverted joystick for optimal ergonomics 
   Exceptionally smooth and responsive micropipette movement
   Variable movement range - 6 settings from coarse to ultra-fine   
   User definable memory positions, including “Work” and z-axis lower limit
   A wide 25mm of travel in all three axes

                             


XENOWORKS
DIGITAL MICROINJECTOR

   Independent “hold” and inject/transfer channels
   Up to 5,600 hPa of injection pressure
   Remote keypad with rotary controls and high- visibility
   LED displays

 

                                










XENOWORKS
ANALOG MICROINJECTOR

   Highly stabble, drift free
   Coaial coarse and fine displacement (10:1 ratio) for fast filling and precision
      control
   Use with a variety of hydraulic fluids,
including oil, air and water
   Interchangeable syringes (500µl standard, 100µl and 1000µl options)

 

                                

Specifications XenoWorks 

XenoWorks MICROMANIPULATOR INPUT DEVICE
Height- and resistance-adjustable inverted joystick with integral declutch, 6 position rotary range control, low-profile base
RANGE SETTINGS (ONE FULL JOYSTICK SWING) 12mm; 3.3mm; 880µm; 400µm; 200µm; 100µm 
MICROPIPETTE POSITION MEMORY 1 user-defined set-point – “Work”;  1 user-defined z-axis limit –
“Floor”; 2 preset points – “Home” and “Setup”
MAXIMUM MOTOR SPEED / TRAVEL RANGE  5.5mms-1 / 25mm
MICROPIPETTE HOLDER GRIP 4mm outer diameter
ELECTRICAL

115/230 Volts50/60 Hertz
XenoWorks DIGITAL MICROINJECTOR FUNCTIONS Hold, Inject, Transfer, Clear
PRESSURE CHANNELS  1 Hold, 1 Inject/Transfer
PRESSURE RANGE  Hold:  -350 to +350 hPa, 7hPa steps
Inject: 0 – 5,600 hPa, 7hPa steps
Transfer: -175 to +175 hPa, 7hPa steps
INJECTION DURATION Variable: 0.01 – 10s in 0.1s increments
INJECTION ACTIVATION Hand- or foot-switch
MICROPIPETTE COMPATIBILITY 1mm O.D. capillary glass / other sizes available upon request
ELECTRICAL

110 or 220 Volts (please specify) 50/60 Hertz
XenoWorks ANALOG MICROINJECTOR
COARSE : FINE RATIO  10:1
INTERCHANGEABLE SYRINGE RESERVOIR  1000µl, 500µl, 100µl
DISPLACEMENT / TURN 500µl syringe – 5.2µl coarse, 0.5µl fine
1000µl syringe – 10.4µl coarse, 1.04µl fine
TUBING 1m ETFE
MICROPIPETTE HOLDER Diameter: 4mm
Accepts:1mm O.D. capillary glass (other sizes can be upon request)
ELECTRICAL 115/230 Volts50/60 Hertz

Microinjection Systems    Products