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SEC
series systems are versatile intracellular recording systems. SEC
systems are the fastest and most accurate single-electrode current
- and voltage - clamp systems available.
These amplifiers are suitable for recordings with high resistance
microelectrodes, for tight-seal perforated patch, or whole-cell
recording techniques. They also allow intracellular recordings
during in vivo voltammetry experiments. Currently, SEC amplifiers
are used in vertebrate (rat, mouse, cat, fish etc.) and
invertebrate (leech, crab, snail, insect etc.) neurons, muscle
cells, other excitable tissue and plant cells.
A significant improvement over other time-sharing amplifiers is
that the SEC systems fully compensate the recording
microelectrode. This
allows single electrode recordings with the same accuracy and
speed of response as with the standard two electrode voltage clamp
approach.
All systems include four (optionally six) modes of operation,
many automatic functions,
protection circuits, versatile I/O signal conditioning units, and
digitally controlled operation. All of these features make these
amplifiers the ideal research instruments for all
electrophysiological investigations using intracellular
microelectrodes or suction electrodes (patch pipettes). SEC
systems are also available as modules for the EPMS-07 system. The
combination of two or more SEC modules results in a convenient
instrument for recording in coupled cells.
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